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Storage Compliance Follow product-specific storage conditions to maintain identity, purity, and biological activity
10.1016/j.cell.2011.10.026 72 MonieriM.RainoneP.SacchiA.GoriA.GasparriA
Mechanical force from a direct stream can shear the peptide chains and permanently damage potency
Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team
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